Evidence Synthesis

Evidence Synthesis & HTA

Systematic reviews, meta-analyses, and HTA dossiers — prepared for review against PRISMA, GRADE, and agency standards.

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What this service is

Systematic reviews, meta-analyses, indirect comparisons, GRADE appraisal, and HTA dossier support that meet the methodological standards expected by Cochrane, agency reviewers, and high-impact journals.

When you need it

Systematic Review Preparation

Preparing a manuscript that requires a defensible systematic review.

HTA Dossier Submission

Submitting an HTA dossier (e.g., NICE, CADTH, IQWiG, PBAC).

Focused Literature Review

Needing a focused literature review for a submission, grant, or business case.

Indirect Treatment Comparison

Conducting an indirect treatment comparison or network meta-analysis.

Real-World Evidence Synthesis

Needing real-world evidence synthesis for a payer or formulary submission.

Our methodology

1
Protocol Development
Protocol development (PICO/PICOS, PROSPERO registration support).
2
Search Strategy
Search strategy (Cochrane-quality, peer-reviewed, documented).
3
Screening & Data Extraction
Dual-reviewer screening and standardised data extraction (Rayyan/Covidence).
4
Risk-of-Bias Appraisal
Risk-of-bias appraisal (Cochrane RoB 2, ROBINS-I, AMSTAR-2).
5
Synthesis & Meta-Analysis
Synthesis and meta-analysis; heterogeneity and sensitivity analyses.
6
GRADE Assessment
GRADE certainty assessment per outcome.
7
PRISMA 2020 Reporting
PRISMA 2020-compliant reporting (checklist + flow diagram).

Deliverables

Protocol document. Search strategy log. Screening and extraction data files. Risk-of-bias / quality-appraisal tables. Manuscript or HTA dossier. Supplementary materials (PRISMA checklist, flow diagram, GRADE profiles).

Standards & tooling

PRISMA 2020 GRADE Cochrane Handbook AMSTAR-2, MOOSE, CHEERS where applicable Agency templates (NICE, CADTH, IQWiG, PBAC, ICER)

Outputs are designed for journal submission and peer-review readiness (publication is not guaranteed).

Typical turnaround: Typically 6–16 weeks (scope-dependent).

Ready to move your manuscript forward?

Let's discuss your project timeline, journal strategy, and how our PhD-level writers can help.

Request a consultation

Tell us about your project and we'll reach out within 24 hours.

We'll respond within 24h. All inquiries are confidential.

Ready to advance your research?

From hypothesis to peer-review — let's scope a tailored plan for your lab.

Scope your evidence synthesis project Request a Consultation

NDA protected · You own 100% of deliverables · Milestone-based